电子邮件：shenxu@zhku.edu.cn

通讯地址：广州海珠区仲恺路501号

教研室：动物遗传育种与繁殖

简介

沈栩，女，博士，副研究员。现为金沙检测线路js69专任教师、“广东省水禽健康养殖科技创新平台”骨干成员。长期从事禽类功能基因组研究，重点研究禽类繁殖特性(季节性繁殖行为和就巢行为)的分子调控机制，先后承担了多项与本项目相关的国家级和省 部级课题。

教育背景

2008-09 至 2011-06, 华南农业大学, 动物遗传育种与繁殖, 博士

2005-09 至 2008-06, 华南农业大学, 动物遗传育种与繁殖, 硕士

2001-09 至 2005-06, 华南农业大学, 动物科学, 学士

工作经历

2021-01 至 今, 仲恺农业工程学院, 金沙检测线路js69, 副研究员

2019-06 至 2020-12, 仲恺农业工程学院, 金沙检测线路js69, 讲师

2014-11 至 2019-06, 中山大学, 生命科学学院, 助理研究员

2011-10 至2014-10，中国科学院北京基因组研究所，博士后

主讲课程

《分子生物学》 《细胞生物学》

研究领域

禽类功能基因组研究，重点围绕禽类繁殖特性(季节性繁殖行为和就巢行为)相关的表观遗传调控机制。

承担主要项目

1. 国家自然科学基金-青年项目： 转录因子NR5A1 介导的多基因调控网络影响鸡就巢性状的遗传和进化机制（31301010）, 2014/01-2016/12, 主持；

2. 中国博士后科学基金-面上项目：转录因子NR5A1和Egr1参与家鸡繁殖性状调控的分子机制（2012M520359），2012/09-2013/10，主持；

3. 广州市科技计划基础与应用基础研究项目：鹅下丘脑光周期应答基因的鉴定及其影响GnRH表达的分子调控机制（202102080162），2021/04-2024/03），主持；

4. 广东省基础与应用基础研究基金-面上项目：光周期调控鹅垂体PT部thyrotroph细胞季节性分泌TSH的分子机制（2021A1515010781）, 2021/01- 2023/12,主持；

5. 广东省重点建设学科科研能力提升项目:马岗鹅下丘脑 MBH 区 tanycytes 细胞脱碘酶系统对光周期应答的表观调控机制研究(2021ZDJS006), 2022/01-2024/12, 主持。

代表性论著

1. Jiaxin Liu#, Yanglong Xu#, Yushuai, Wang, Jinning, Zhang, Yuting Fu, Sui Liufu, Danli Jiang, Jianqiu Pan, Hongjia Ouyang, Yunmao Huang*, Yunbo Tian*, Xu Shen*. The DNA Methylation Status of the Serotonin Metabolic Pathway Associated with Reproductive Inactivation Induced by Long-Light Exposure in Magang geese. BMC Genomics, Accept.

2. Jun Tang, Hongjia Ouyang , Xiaomei Chen, Danli Jiang, Yunbo Tian, Yunmao Huang, Xu Shen. Comparative Transcriptome Analyses of Leg Muscle during Early Growth between Geese ( Anser cygnoides) Breeds Differing in Body Size Characteristics. Genes (Basel). 2023 May 7;14(5):1048.  doi: 10.3390/genes14051048.

3. Jianye Chang, Di Fan, Jiaxin Liu, Yanglong Xu, Xuefei Huang, Yunbo Tian, Jin Xu, Yunmao Huang, Jue Ruan*, Xu Shen*. Transcriptomic and Chromatin Landscape Analysis Reveals That Involvement of Pituitary Level Transcription Factors Modulate Incubation Behaviors of Magang Geese. Genes (Basel). 2023 Mar 28;14(4):815. doi: 10.3390/genes14040815.

4. Yanglong Xu, Danli Jiang, Jiaxin Liu , Yuting Fu, Yan Song, Di Fan, Xuefei Huang, Sui Liufu, Jianqiu Pan, Hongjia Ouyang, Yunbo Tian, Xu Shen*, Yunmao Huang*. Photoperiodic Changes in Both Hypothalamus Neurotransmitters and Circulating Gonadal Steroids Metabolomic Profiles in Relation to Seasonal Reproduction in Male Quail. Front Physiol. 2022 Mar 25;13:824228. doi: 10.3389/fphys.2022.824228. eCollection 2022.

5. Xu Shen, XueBai, Chenlong Luo, Danli Jiang, Xiujin Li, Xumeng Zhang, Yunbo Tian, Yunmao Huang. Quantitative proteomic analysis of chicken serum reveals key proteins affecting follicle development during reproductive phase transitions. Poultry Science, 2021,100(1):325-333. doi: 10.1016/j.psj.2020.09.058

6. Yuezheng Zhang#, Yawei Li#, Tao Li#, Xu Shen#, Tianqi Zhu, Yong Tao, Xueying Li, Di Wang,  Qin Ma, Zheng Hu, Jialin Liu, Jue Ruan, Jun Cai, Hurng-Yi Wang, Xuemei Lu. Genetic load and potential mutational meltdown in cancer cell populations.Molecular Biology and Evolution, 2019, 1;36(3):541-552. doi: 10.1093/molbev/msy231

7. Guangan Lu, Yixin Zhao, Hao Yang, Ao Lan, Suhua Shi, Zhongqi Liufu, Yao Huang, Tian Tang, Jin Xu, Xu Shen*, Chung-I Wu*. Death of new microRNA genes in Drosophila via gradual loss of fitness advantages. Genome Research. 2018, 28(9):1309-1318.

8. Shen Xu，Bai Xue，Xu Jin，Zhou Min，Xu Haipin，Nie Qinghua，Lu Xuemei ，Zhang Xiquan . Transcriptome sequencing reveals genetic mechanisms underlying the transition between the laying and brooding phases and gene expression changes associated with divergent reproductive phenotypes in chickens. Mol Biol Rep, 2016,43(9)：977~989.

9. Shen X , Zeng H, Xie L, He J, Li J, Xie X, Luo C, Xu H, Zhou M, Nie Q, Zhang X, The GTPase activating Rap/RanGAP domain-like 1 gene is associated with chicken reproductive traits. PLoS One. 2012,7(4):e33851.

10. Xu H # , Shen X # (Contributed), Zhou M, Fang M, Zeng H, Nie Q, Zhang X. The genetic effects of the dopamine D1 receptor gene on chicken egg production and broodiness traits. BMC Genet. 2010, 11:17.

专利及其他成果

张细权、沈栩、曾华、谢亮. 与鸡 300 日龄产蛋量相关的 GARNL1 基因上的位点及其应用. 2012.12. 中国. ZL 2010 10280382.X

阮珏，王开乐，沈栩，吕雪梅，吴仲义. 一种DNA扩增方法. 2019.05.17. 中国，ZL 2014 10448896.X