赵丽娟
赵丽娟，女, 水产养殖专业，农学博士，
E-mail: zhaolijuan4234@163.com；
通信地址： 广州市海珠区仲恺路501号金沙检测线路js69；
邮编：510225
个人概述：
赵丽娟，现工作于金沙检测线路js69，副教授。大学毕业于烟台大学，淡水养殖专业，随后在大连海洋大学获得硕士学位，华中农业大学获得博士学位，2014-2015年从事水产品质量安全检测工作，于2016-2018年脱产从事博士后学习。大学毕业后，在山东省淡水渔业研究院工作，主要负责水产动物的繁殖育种、养殖和疾病防控以及国外优良品种的引进与培育，有8年的一线生产经验。养殖对象主要包括罗非鱼、淡水白鲳、巴沙鱼、南美白对虾、黄颡鱼、海参、彩虹鲷、鳗鲡、史氏鲟、翘嘴红鲌以及“四大家鱼”等常见鲤科鱼类、引进品种有淡水黑鲷、宝石鲈、俄罗斯鲤鱼等。
科研方面自2005年攻读硕士后一直从事水产营养、疾病与免疫学相关研究工作；2019年1月自山东省淡水渔业研究院调入仲恺农业工程学院。主持基金项目包括国家自然科学基金青年基金（31602190），博士后基金（2016M602327），广东省农业农村厅和广东省科技厅项目各1项，校冲补强项目1项，合计金额150万元。到目前为止，共发表论文50多篇，其中SCI 收录37篇，其中第一或通讯作者SCI文章7篇（ JCR一区4篇，JCR三区2篇，JCR四区1篇），中文收录16篇，第一或通讯作者中文文章6篇。专利1篇。为广东省“水产疫病监测与综合防控共性关键技术研发创新团队”专家。
主要研究兴趣：
1. 水产动物疾病与健康养殖
2. 细菌耐药性与抗生素替代品研发
3. 微生物功能因子鉴定与研究
4. 益生菌、益生元、抗菌肽、免疫添加剂研发
5. 养殖尾水处理与养殖工程
教育背景：
时 间 |
大 学 |
专 业 |
学 位 |
2015/8-2018/12 |
华中农业大学 |
兽医方向 |
博士后 |
2009/9-2013/7 |
华中农业大学 |
水产养殖专业 |
博士 |
2005/9-2008/7 |
大连海洋大学 |
动物营养与饲料科学专业 |
硕士 |
1998/9-2000/7 |
烟台大学 |
淡水养殖专业 |
大专 |
工作经历：
2019.1-至今 |
仲恺农业工程学院 |
金沙检测线路js69 |
水产系 |
2014.1-2018.12 |
山东省淡水渔业研究院 |
水产品资质检定中心 |
药残检测 |
2013.06-2013.12 |
中科院水生生物研究所 |
聂品研究员实验室 |
黄杆菌胞外多糖相关研究
|
2008.8-2009.8 |
山东省淡水渔业研究院 |
水产病害研究 |
|
2002.4-2005.8 |
山东省淡水渔业研究院 |
水产养殖引种、繁育、养成、病害等相关工作
|
|
2000.7-2002.2 |
山东省胶州市国家级罗非鱼良种场 |
水产养殖相关工作 |
近几年主持项目情况：
（1）广东省农业农村厅项目，水产疫病监测与综合防控共性关键技术研发创新团队专家，主持，35万，2019/01-2023/12。
（2）2020年省级乡村战略专项资金（渔业发展项目）--广东省水产养殖规范用药项目，主持，50万，2020/01-2021/12
（3）2019年仲恺农业工程学院国家与省基金培育项目，主持，6万，2019/01-2020/12
（4）国家自然科学基金，青年基金项目编号为31602190，题目：MiR-155靶向踝蛋白抑制柱状黄杆菌诱导EPC细胞凋亡的机制研究，主持，25万，2017/01-2019/12。
（5）博士后自然科学基金，面上基金资助编号2016M602327，题目：miRNA-155调节柱状黄杆菌诱导EPC细胞凋亡的机制研究，主持，5万，2017/01-2018/12。
近几年发表的主要论文：(以发表时间为序，*为通信作者,+为共同第一作者；JCR分区采用美国JCR系统)
英语文章：
1. Zhendong Qin, V. Sarath Babu, Hanzuo Lin, Yunjia Dai, Lijuan Zhao, Jungang Xie, Weiqiang Lin, Zaohe Wu, Jun Li*, Li Lin*. Antibacterial activity of erythrocyte from grass carp (Ctenopharyngodon idella) is associated with phagocytosis and reactive oxygen species generation. Fish Shellfish Immunol. 2019, accepted. SCI:3.02.（JCR 一区刊物）.
2. Muhammad Asim, V. Sarath Babu, Zhendong Qin, Lijuan Zhao, Jianguo Su, Jun Li, Jiagang Tu, Hongyan Kou*, Li Lin*. Inhibition of Cyclophilin A on the Replication of Red Spotted Grouper Nervous Necrosis Virus associates with multiple pro-inflammatory factors. Fish Shellfish Immunol. 2019, accepted. SCI:3.02.（JCR 一区刊物）.
3. Zhendong Qin, V. Sarath Babu, Hanzuo Lin, Yunjia Dai, Hongyan Kou, Liehuan Chen, Jun Li, Lijuan Zhao*, Li Lin*.The immune function of prophenoloxidase from red swamp crayfish (Procambarus clarkii) in response to bacterial infection. Fish Shellfish Immunol. 2019, accepted. SCI:3.02.（JCR 一区刊物）.
4. Farman Ullah Dawar, Sarath Babu V, Hongyan Kou, Zhendong Qin, Quanyuan Wan, Lijuan Zhao, Muhammad Nasir Khan Khattack, Jun Li, Jie Mei*, Li Lin*.The rag 2 gene of yellow catfish (Tachysurus fulvidraco) and its immune response against Edwardsiella ictaluri infection. Dev Comp Immunol, 2019,16;98:65-75.2019. SCI IF:2.815. （ JCR一区刊物）
5. Xiaodan Liu, Zhendong Qin, Sarath Babu V, Lijuan Zhao, Jun Li, Xiaojun Zhang, Li Lin*. Transcriptomic profiles of striped snakehead cells (SSN-1) infected with snakehead vesiculovirus (SHVV) identifying IFI35 as a positive factor for SHVV Replication. Fish Shellfish Immunol. 2019 Mar;86:46-52, SCI:3.02.（JCR 一区刊物）.
6. Meng Zhou, Quanyuan Wan, Sarath Babu V, Qiongju Qiu, Hongyan Kou, Chong Lin, Lijuan Zhao, Ling Yang, Jun Li, Yunmao Huang*, Li Lin*. Bacterial features in tilapia (Oreochromis niloticus) and environments in a goose-tilapia polyculture model. Aquaculture, 2018, 497: 313-319, SCI:2.57.（JCR Q1）.
7. Zhendong Qin+, V Sarath Babu+, Ningqiu Li, Tairan Fu, Jinquan Li, Lizhu Yi, Lijuan Zhao, Jun Li, Yang Zhou*, Li Lin*. Protective effects of chicken egg yolk immunoglobulins (IgY) against experimental Aeromonas hydrophila infection in Blunt snout bream (Megalobrama amblycephala) . Fish Shellfish Immunol. 2018 Jul;78:26-34. SCI:3.02.（JCR 一区刊物）.
8. Zhendong Qin, V. Sarath Babu, Quanyuan Wan, Meng Zhou, Risheng Liang, Asim Muhammad, Lijuan Zhao, Jun Li, Jiangfeng Lan* , Li Lin*. Transcriptome analysis of Pacific white shrimp (Litopenaeus vannamei) challenged by Vibrio parahaemolyticus reveals unique immune-related genes . Fish Shellfish Immunol. 2018 Jun;77:164-174. SCI:3.02.（JCR 一区刊物）.
9 .Xiaolei Wei, V. Sarath Babu, Li Lin, Yazhen Hu, Yulei Zhang, Xiaoling Liu, Jianguo Su, Jun Li, Lijuan Zhao*, Gailing Yuan*· Hepcidin protects grass carp (Ctenopharyngodon idellus) against Flavobacterium columnare infection via regulatin iron distribution and immune gene expression. Fish & Shellfish Immunology, 75: 274-283. April 2018.（JCR一区刊物）
10. Chi Zhang, Shuangshuang Feng, Wenting Zhang, Nan Chen, Abeer Hegazy,Wenjie Chen, Xueqin Liu, Lijuan Zhao, Jun Li, Li Lin* and Jiagang Tu*. MicroRNA miR-214 Inhibits Snakehead Vesiculovirus Replication by Promoting IFN-α Expression via Targeting Host Adenosine 5’-Monophosphate-Activated Protein Kinase. Frontiers in Immunology, 2017 Dec 11;8:1775. SCI: 6.4.（JCR 一区刊物）.
11. Farman Ullah Dawar, Xianqin Hu, Lijuan Zhao, Xingxing Dong, Yang Xiong, Meng Zhou, Rishen Liang, V Sarath Babu, Jun Li, Jie Mei*, Li Lin* .Transcriptomic analysis reveals differentially expressed genes and a unique apoptosis pathway in channel catfish ovary cells after infection with the channel catfish virus. Fish Shellfish Immunol. 2017 Sep 29;71:58-68. SCI:3.02.（JCR 一区刊物）.
12. Zhang Y, Zhao L*, Chen W, Huang Y, Yang L, Sarathbabu V, Wu Z, Li J, Nie P*, Lin L*. Complete genome sequence analysis of the fish pathogen Flavobacterium columnare provides insights into antibiotic resistance and pathogenicity related genes. Microb Pathog. 2017 Sep 1;111:203-211 SCI : 2.0. （JCR 三区刊物）
13. Lin Q, Fu X, Li N, Wan Q, Chen W, Huang Y, Huang Z, Li J, Zhao L*, Lin L*. Co-infections of infectious spleen and kidney necrosis virus and Siniperca chuatsi rhabdovirus in Chinese perch (Siniperca chuatsi). Microb Pathog. 2017 Sep 7;111:422-430. SCI : 2.0. （JCR 三区刊物）
14. Lindan Sun+, Jiagang Tu+, Lizhu Yi, Wenjie Chen, Lijuan Zhao, Yunmao Huang, Rishen Liang, Jun Li, Meng Zhou*, Li Lin*. Pathogenicity of snakehead vesiculovirus in rice field eels (Monopterus albus). Microb Pathog. 2017 Sep;110:578-585. SCI : 2.0. （JCR 三区刊物）
15. Chi Zhang, Lizhu Yi, Shuangshuang Feng, Xueqin Liu, Jianguo Su, Li Lin, Jiagang Tu*. MicroRNA miR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting the coding regions of viral N and P. Journal of General Virology, 2017 Jul;98(7):1611-1619. SCI IF :3.2. （JCR 三区刊物）
16.Jiali Jin+, Yao Wang+, Zhixin Wu, Abeer Hergazy, Jiangfeng Lan, Lijuan Zhao， Xiaoling Liu, Nan Chen*, Li Lin*.Transcriptomic analysis of liver from grass carp (Ctenopharyngodon idellus) exposed to high environmental ammonia reveals the activation of antioxidant and apoptosis pathways. Fish Shellfish Immunol. 2017 Apr;63:444-451 SCI:3.02.（JCR 一区刊物）
17. Wenjie Chen, Lizhu Yi, Shuangshuang Feng, Lijuan Zhao, Jun Li, Meng Zhou, Rishen Liang, Na Gu, Zaohe Wu, Jiagang Tu*, Li Lin*. Characterization of microRNAs in orange-spotted grouper (Epinephelus coioides) fin cells upon red-spotted grouper nervous necrosis virus infection.Fish Shellfish Immunol. 2017, 63:228-236. SCI:3.02.（JCR 一区刊物）
18. Ze Zhang, Angen Yu, Jiangfeng Lan, Hua Zhang , Minqiang Hu, Jiewei Cheng, Lijuan Zhao, Li Lin*, Shun Wei*. GapA, a potential vaccine candidate antigen against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunol. 2017, 63:255-260.SCI:3.02.（JCR 一区刊物）
19. Yun-Jia Dai, Kai-Min Hui, Ying-Hao Zhang, Yan Liu, Yu-Qing Wang, Li-Juan Zhao, Li Lin, Lian-Qin Chai, Shun Wei, Jiangfeng Lan. Three STATs are involved in the regulation of the expression of antimicrobial peptides in the triangle sail mussel, Hyriopsis cumingii. Fish Shellfish Immunol. 2017 Apr;63:181-188. SCI:3.02.（JCR 一区刊物）
20. Xiaozhe Fu, Xianqin Hu, Ningqiu Li*, Feifei Zheng, Xingxing Dong, Jing Duan, Qiang Lin, Jiagang Tu, Lijuan Zhao, Zhibin Huang, Jianguo Su, Li Lin*. Glutamine and glutaminolysis are required for efficient replication of infectious spleen and kidney necrosis virus in Chinese perch brain cells. Oncotarget, 2017, Vol. 8, (No. 2), pp: 2400-2412. SCI :5.08 (JCR 一区刊物).
21. Farman Ullah Dawar, Junjie Wu, Lijuan Zhao, Muhammad Nasir Khan Khattak, Jie Mei*, Li Lin*. Updates in understanding the role of cyclophilin A in leukocyte chemotaxis. Journal of Leukocytes Biology. 2017 Apr;101(4):823-826 ; SCI IF :4.16. （JCR 一区刊物）
22. Yunjia Dai, Yuqing Wang, Yinghao Zhang,Yan Liu, Jinquan Li, Shun Wei, Lijuan Zhao,Yongcan Zhou, Li Lin*, Jiangfeng Lan*. The role of ficolin-like protein (PcFLP1) in the antibacterial immunity of red swamp crayfish (Procambarus clarkii). Molecular Immunology. 2016 Nov 23;81:26-34. SCI:3.23(JCR三区刊物)
23. Muhammad Asim, Sanjie Jiang, Lizhu Yi, Wenjie Chen, Lindan Sun, Lijuan Zhao, Muhammad Nasir Khan Khattak, Jiagang Tu*, Li Lin*. Glutamine is required for red-spotted grouper nervous necrosis virus replication via replenishing the tricarboxylic acid cycle. Virus Research. 2016, 227:245-248. SCI :2.7（JCR 三区刊物）
24. Jiangfeng lan, Lijuan Zhao, Shun Wei, Yuan Wang, Li Lin, Xincang Li. PcToll2 positively regulates the expression of antimicrobial peptides by promoting PcATF4 translocation into the nucleus. Fish Shellfish Immunol. 2016 Sep 10;58:59-66. SCI:3.02.（JCR 一区刊物）
25. Lindan Sun, Lizhu Yi, Chi Zhang, Xiaodan Liu, Shuangshuang Feng, Wenjie Chen, Jiangfeng Lan, Lijuan Zhao, Jiagang Tu*, Li Lin*. Glutamine was required for snakehead fish vesiculovirus (SHVV) propagation via replenishing the tricarboxylic acid cycle. Journal of General Virology, 2016 Nov;97(11):2849-2855. SCI IF :3.2（ JCR三区刊物）
26. Jiang-Feng Lan, Shun Wei, Yu-Qing Wang, Yun-Jia Dai, Jia-Gang Tu, Li-Juan Zhao, Xin-Cang Li, Qi-Wei Qin, Nan Chen*, Li Lin*. PcToll3 positively regulates the expression of antimicrobial peptides by promoting PcDorsal translocation into nucleus in red swamp crayfish, Procambarus clarkii. Fish and Shellfish Immunology, 2016, 57:17-24. SCI:3.02.（JCR 一区刊物）
27. Lijuan Zhao+, Jiagang Tu+, Yulei Zhang, Jinfu Wang, Ling Yang, Weimin Wang, Zaohe Wu, Qinglei Meng*, Li Lin*.Transcriptomic analysis of the head kidney of Topmouth culter (Culter alburnus) infected with Flavobacterium columnare with an emphasis on phagosome pathway. Fish and Shellfish Immunology, 2016 Oct;57:413-8. SCI:3.02.（JCR 一区刊物）
28. Yao Wang, Nan Chen, Abeer M. Hegazy, Xiaodan Liu, Zhixin Wu , Xueqin Liu, Lijuan Zhao, Qiwei Qin, Jiangfeng Lan*, Li Lin*. Autophagy induced by Snakehead fish vesiculovirus inhibited its replication in SSN-1 cell line. Fish and Shellfish Immunology, 2016, 55:415-422. SCI:3.02.（JCR 一区刊物）
29. Zhao LL, Wang YQ, Dai YJ, Zhao LJ, Qin Q, Lin L, Ren Q, Lan JF. A novel C-type lectin with four CRDs is involved in the regulation of antimicrobial peptide gene expression in Hyriopsis cumingii. Fish and Shellfish Immunology, 2016, 55:339-347. SCI:3.02.（JCR 一区刊物）
30. Yunjia Dai, Yuqing Wang, Lingling Zhao, Zhendong Qin, Junfa Yuan, Qiwei Qin, Li Lin*, Jiangfeng Lan*. A novel L-type lectin was required for the multiplication of WSSV in red swamp crayfish (Procambarus clakii). Fish and Shellfish Immunology, 2016, 55:48-55. SCI : 3.02.（JCR 一区刊物）
31. Jiagang Tu+, Wenjie Chen+, Xiaozhe Fu, Qiang Lin, Ouqin Chang, Lijuan Zhao,Jiangfeng Lan*, Ningqiu Li *, Li Lin *.Susceptibility of Chinese perch brain (CPB) cell and Mandarin fish to Red-spotted grouper nervous necrosis virus (RGNNV) infection. Int J Mol Sci. 2016, May 19;17(5). pii: E740. doi: 10.3390/ijms17050740. SCI IF : 3.2（ JCR四区刊物）
32. Zhao L, Lu H, Meng Q, Wang J, Wang W, Yang L*, Lin L*. Profilings of MicroRNAs in the·· Liver of Common Carp (Cyprinus carpio) Infected with Flavobacterium columnare. Int J Mol Sci. 2016 Apr 15;17(4). pii: E566. doi: 10.3390/ijms17040566. SCI IF : 3.2（ JCR四区刊物）
33.Xiaodan Liu, Jiagang Tu, Junfa Yuan，Xueqin Liu, Lijuan Zhao，Farman Ullah Dawar，Muhammad Nasir Khan Khattak，Abeer M Hegazy，Nan Chen，Vikram N Vakharia, Li Lin*. Identification and Characterization of MicroRNAs in Snakehead Fish Cell Line upon Snakehead Fish Vesiculovirus Infection. International Journal of Molecular Sciences，2016，17(2)：12-16. SCI IF : 3.2（ JCR四区刊物）
34. Feifei Zheng, Muhammad Asim, Jiangfeng Lan, Lijuan Zhao, Shun Wei, Nan Chen, Xiaolin Liu, Yang Zhou*, Li Lin*.Molecular Cloning and Functional Characterization of Mannose Receptor in Zebra Fish (Danio rerio) during Infection with Aeromonas Sobria. International Journal of Molecular Sciences, 2015 ,16(5):10997-1012. SCI IF : 2.862（ JCR四区刊物）
35. Xianqin Hu, Xiaozhe Fu, Ningqiu Li*, Xingxing Dong,Lijuan Zhao,Jiangfeng Lan,Wei Ji,Weidong Zhou, Taoshan Ai, Shuqin Wu, Li Lin*. Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways. Fish and Shellfish Immunology, 2015, 45 : 619-629. SCI IF: 2.674..（ JCR一区刊物）
36. Li Juan Zhao，Jin Fang Lu，P. Nie, Ai Hua Li, Bang Xi Xiong, Hai Xia Xie. Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiella ictaluri. Veterinary Microbiology, 2013, 166, 233–241. （JCR一区刊物）
37. Shan Nan Chen, Bei Huang, Xiao Wen Zhang, Ye Li, Li Juan Zhao, Nan Li, Qian Gao, P. Nie. IFN-c and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates. Developmental and Comparative Immunology, 2013, 41, 587–596. （JCR二区刊物）
· 中文刊物：
1. 资英娟,秦真东，詹凡玢，谢昊堃,张瀚云，黎 烽，李滨， 赵皓翰，谢远崧，赵丽娟*，林蠡*.一株保护草鱼肠道和改善水质的枯草芽孢杆菌的分离鉴定及全基因组分析.水产学报, 2020, 44(7): 1173−1186.
2. 王玟秀，秦真东，Sarath Bubu V，周萌，梁日深，莫金凤，吴灶和，张轩, 赵丽娟*，林蠡*. 抑制气呼吸导致大鳞副泥鳅 (Paramisgurnus dabryanus) 主要呼吸器官的组织病理变化观察. 水产学报, （已接收）
3. 李嘉波，秦真东，赵丽娟，刘志刚，可小丽，吴灶和，刘小玲，卢迈新*，林蠡*. 罗非鱼湖病毒对尼罗罗非鱼(Oreochromis niloticus）和E-11细胞的感染研究. 水产学报, （已接收）
4. 何昕，秦真东，张凯，梁日深，杨森，伍剑标, 赵丽娟*，林蠡*. 苏丹鱼（Leptobarbus hoevenii）甘露糖受体的基因克隆表达和免疫特性研究. 水产学报, 2020, 44(3): 378−390
5. 苏国茂，秦真东，李嘉波，周萌，莫金凤，张凯，梁日深，吴灶和，赵丽娟*，林蠡*. 罗湖病毒核蛋白的克隆表达、抗体制备及其组织分布研究. 水产学报, 2020, 44(2): 276−288
6. 卢志杰，叶成凯，Sarath Babu V，张晓君，刘晓丹，赵丽娟，潘淦*，林蠡*.罗氏沼虾谷氨酰胺合成酶基因的克隆与表达. 水产学报, 2019,43(03):549-562.
7. 叶成凯，卢志杰，Sarath Babu V，张晓君，刘晓丹，赵丽娟，潘凎*，林 蠡*.罗氏沼虾几丁质酶3B基因的克隆及其在蜕皮周期中的表达. 水产学报, 2019(04):751-762.
8. 付泰然，刘广鑫，万全元，吴霆，赵丽娟，杨灵*，林蠡*. 基于栈式自编码BP神经网络预测水体亚硝态氮浓度模型. 水产学报, 2019(04):958-967.
9. 冯燕,秦真东,代云佳,张玉蕾,刘小玲,周洋,兰江风,赵丽娟*,林蠡*.草鱼核因子E2相关因子2基因克隆分析及其对呼吸爆发的调控作用[J].水产学报,2018,42(02):161-177
10. 段静,刘广鑫,董晏君,周洋,李锦铨,刘小玲,周萌,梁日深,赵丽娟*,林蠡*.解淀粉芽孢杆菌HZ-1510壳聚糖酶基因的克隆、重组表达及其活性[J].水产学报,2017,41(10):1552-1561.
11. 林蠡,赵丽娟,陈文捷.采用三套环理论指导水产疾病高效防控，科学养鱼，2016,32(1):59-60.
12. 胡先勤，付小哲，董星星，涂加钢，赵丽娟，林强，李宁求，林蠡*. 鳜亲环蛋白A在传染性脾肾坏死病毒增殖中的作用.水产学报，2016，40(1):100-109
13. 张玉蕾，赵丽娟，周伟东,艾桃山,林蠡*.黄颡鱼源柱状黄杆菌对鳜鱼的致病性研究. 华中农业大学学报.2016.35:83-39.
14. 王吉桥，赵丽娟，姜玉生，张剑诚，王锡荣.饲料中不同脂肪酸搭配对仿刺参幼参生长和体组分的影响.渔业科学进展,2009.30: 62-73.
15. 王吉桥，赵丽娟,苏久旺,姜玉声,蒋湘辉,孙丕海,张剑诚.饲料中脂肪及乳化剂含量对仿刺参幼参生长和体组成的影响.大连水产学院学报,2009.24:17-23.
16. 王吉桥，赵丽娟,孙丕海,李帆,张建诚,王文辉.L-肉毒碱在鱼类饲料中应用.北京水产,2006.4:38-42.
· 专利：
1. 一种高致病性嗜水气单胞菌及应用，发明专利，发明人：周洋、李锦铨、林蠡、赵丽娟、王小红、李智、喻蔚，授权时间：2018年5月8日，（ZL201610242186.0）
